Shine on MS - A Major Multiple Sclerosis Movement is now in Progress!

Shine on MS - A Major Multiple Sclerosis Movement is now in Progress!

MS stars unite to back a global movement to End MS

/PressPort/ -- MS Station Inc. (MSstation.com and MSstation.TV) along with ‘Shine On MS’ (www.Shineonms.com) are uniting the MS Community on a Grand and Global Scale!!

NEVER FEEL ALONE WITH A MULTIPLE SCLEROSIS DIAGNOSIS AGAIN!!!!

You can hear us on MSstation.com and see us on MSstation.TV. Now, you can also chat with us on Shine On MS’www.shineonms.com! [http://shineonms.MSstation.com]

MSstation Inc. is Dedicated to Providing Global Awareness, Encouragement and Support for People Affected Directly or Indirectly by Multiple Sclerosis.

Radio Hosts of MSstation.com include a number of affluent people in the Multiple Sclerosis Community. Amy Gurowitz and Stuart Schlossman, are amongst the numbers involved in procuring MSstation Inc.’s Mission.

Amy Gurowitz, Founder of MS softServe www.MSsoftserve.com hosts MSLOL (Multiple Sclerosis Life of Learning) Radiowww.MSLOLradio.com every 1st Wednesday.

MS SoftServe is Dedicated to Customized Learning about Multiple Sclerosis. MS SoftServe will give users control over what and how they learn about their unique version of MS, without exposing them to unwanted information that contribute to their anxiety while living with it”

Stuart Schlossman, Founder of MS Views and News Organization www.MSviewsandnews.org Hosts Stu MS Radiowww.MSStuMSradio.com every 4th Wednesday.

MS Views and News, Inc., is dedicated to the global collection and distribution of current information concerning Multiple Sclerosis. In collaboration with other organizations, MS Views and News (MSV&N) uses state-of-the-art communication channels to provide information for those affected by or interested in MS.

Like the Hosts the Founder Rae-Anne (Rae) Edwards also has Multiple Sclerosis. You don’t have to have MS to Host your own show on MSstation, just a passion to spread Awareness, Encouragement and Support!

About Shine On MS

A social network and community for those affected by Multiple Sclerosis. Shine On MS is a community for people affected by Multiple Sclerosis, MS Groups, researchers, campaigners and activists. Users can share, get support and interact with other members. The social network was created by MS campaigner Ryan Mclaughlin from Scotland. The teenager dedicated the social network to help fight for better rights for those with MS. The young health activist will use the platform as a campaign HQ to launch a worldwide campaign in 2012 to get politicial action taken to end the disease within a generation.

www.shineonms.com

About the Shine on Scotland Campaign

A campaign by 16 year old Ryan Mclaughlin to get vitamin D for every child and pregnant
mother as a preventative measure against Multiple Sclerosis www.shineonscotland.org.uk

For more information, please contact
Shine on MS
Founder Ryan Mclaughlin
www.shineonms.com
Phone 07580 461976

Shine on MS - A Major Multiple Sclerosis Movement is now in Progress!

Shine on MS - A Major Multiple Sclerosis Movement is now in Progress!:

'via Blog this

MS stars unite to back a global movement to End MS

/PressPort/ --MS Station Inc. (MSstation.com and MSstation.TV) along with ‘Shine On MS’ (www.Shineonms.com) are uniting the MS Community on a Grand and Global Scale!!

NEVER FEEL ALONE WITH A MULTIPLE SCLEROSIS DIAGNOSIS AGAIN!!!!


You can hear us on MSstation.com and see us on MSstation.TV. Now, you can also chat with us on Shine On MS’www.shineonms.com! [http://shineonms.MSstation.com]
MSstation Inc. is Dedicated to Providing Global Awareness, Encouragement and Support for People Affected Directly or Indirectly by Multiple Sclerosis.
Radio Hosts of MSstation.com include a number of affluent people in the Multiple Sclerosis Community. Amy Gurowitz and Stuart Schlossman, are amongst the numbers involved in procuring MSstation Inc.’s Mission.
Amy Gurowitz, Founder of MS softServe www.MSsoftserve.com hosts MSLOL (Multiple Sclerosis Life of Learning) Radio www.MSLOLradio.com every 1st Wednesday.

MS SoftServe is Dedicated to Customized Learning about Multiple Sclerosis. MS SoftServe will give users control over what and how they learn about their unique version of MS, without exposing them to unwanted information that contribute to their anxiety while living with it”

Stuart Schlossman, Founder of MS Views and News Organization www.MSviewsandnews.org Hosts Stu MS Radiowww.MSStuMSradio.com every 4th Wednesday.

MS Views and News, Inc., is dedicated to the global collection and distribution of current information concerning Multiple Sclerosis. In collaboration with other organizations, MS Views and News (MSV&N) uses state-of-the-art communication channels to provide information for those affected by or interested in MS.
Like the Hosts the Founder Rae-Anne (Rae) Edwards also has Multiple Sclerosis. You don’t have to have MS to Host your own show on MSstation, just a passion to spread Awareness, Encouragement and Support!

About Shine On MS
A social network and community for those affected by Multiple Sclerosis. Shine On MS is a community for people affected by Multiple Sclerosis, MS Groups, researchers, campaigners and activists. Users can share, get support and interact with other members. The social network was created by MS campaigner Ryan Mclaughlin from Scotland. The teenager dedicated the social network to help fight for better rights for those with MS. The young health activist will use the platform as a campaign HQ to launch a worldwide campaign in 2012 to get politicial action taken to end the disease within a generation.
www.shineonms.com

About the Shine on Scotland Campaign
A campaign by 16 year old Ryan Mclaughlin to get vitamin D for every child and pregnant
mother as a preventative measure against Multiple Sclerosis www.shineonscotland.org.uk

For more information, please contact
Shine on MS - www.shineonms.com - Founder Ryan Mclaughlin - Phone 07580 461976 - Email 

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MS breakthrough: Vitamin D directly terminates production of disease-causing protein

MS breakthrough: Vitamin D directly terminates production of disease-causing protein

Mechanism suggests a potential new path toward pharmaceutical treatment of MS, as well as therapies for other autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, eczema and psoriasis.

For years scientists have noted an association between levels of vitamin D in a person’s body and the person’s ability to resist or minimize the effects of multiple sclerosis (MS) but didn’t understood the mechanism involved. Until now.

New breakthrough research by a collaborative team at UMDNJ-New Jersey Medical School and Stanford indicates that vitamin D directly terminates the production of a disease-causing protein.

As the investigators outline in their report, published in the September issue of Molecular and Cellular Biology (“1,25-Dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A” ):

• During MS (“EAE” in mice), a damaging protein called interleukin-17 (IL-17) is produced by immune cells in the brain.

• The research team found that after vitamin D binds to its receptor, the receptor parks itself on the gene that encodes IL-17.

• By doing so, the vitamin D receptor occupies a site normally reserved for a protein called NFAT, which is required to turn the IL-17 gene on.

• The gene stays off and IL-17 levels plummet.

• At the same time, the vitamin D receptor turns on another gene, whose product generates suppressive T cells that combat the destructive action of their IL-17-producing counterparts.

According to the researchers, led by UMDNJ Prof. Sylvia Christakos, PhD, the mechanism they identified suggests what might be a new path toward pharmaceutical treatment of MS, as well as therapies for other autoimmune diseases that might include rheumatoid arthritis, type 1 diabetes, eczema and psoriasis.

Source: ProHealth Copyright © 2011 ProHealth, Inc. (17/08/11)

Doctors begin major stem cell trial for MS patients

A major clinical trial will investigate whether stem cells can be safely used to treat multiple sclerosis (MS).

It is hoped eventually to slow, stop or even reverse the damage MS causes to the brain and spinal cord.

The trial, involving up to 150 patients across Europe, is due to start later this year.

Dr Paolo Muraro from Imperial College London said: “There is very strong pre-clinical evidence that stem cells might be an effective treatment.”

Researchers will collect stem cells from the bone marrow of patients, grow them in the laboratory and then re-inject them into their blood.

The stem cells will make their way to the brain where it is hoped that they will repair the damage caused by MS.

The research has been part-funded by the UK’s MS Society, which is concerned about the availability of unproven stem cell treatments.

In recent years many people living with MS have been attracted to overseas stem cell clinics which claim to cure long-term conditions in exchange for large amounts of money.

But there is no proven stem cell therapy available for MS anywhere in the world.

The MS Society hopes these new trials will eventually lead to a proven treatment – and a reduction in the draw of overseas treatments.

Common condition

MS is the most common neurological condition to affect young people in the UK.

Three million people are thought to be affected worldwide and up to 100,000 in the UK.

The condition is caused by the body’s own immune system attacking and damaging a substance called myelin in the brain and nerve cells.

The myelin damage disrupts messages from the brain to the body which leads to a number of symptoms such as sight loss, bladder and bowel problems, muscle stiffness and eventually physical disability.

Drugs are available to alleviate the symptoms – but they do not prevent the progression of the condition.

Experiments in test tubes and laboratory animals suggest stem cells extracted from bone marrow may be able to offer a more effective treatment.

Their role in the bone marrow is to protect the cells that make blood. But they also seem to protect myelin from attack by the immune system.

There is also some evidence that these cells might also be able to repair damaged tissue.

Hold potential

Dr Doug Brown, of the MS Society, said: “These experiments have confirmed that these stem cells hold that potential – but these need to be confirmed in large scale clinical trials.”

There is some way to go, however, before laboratory promise can be translated into a treatment that can be offered to patients.

The international team will begin so-called phase two clinical trials in six months’ time designed to determine whether the treatment is safe and effective.

It will take five years to carry out and assess the results of the trials after which large phase three trials may be required.

But Dr Muraro believes that the stem cell approach has real potential.

He said: “The great hope is the fact that we are exploiting a biological system that has evolved over millions of years and harnessing it for treatment that takes advantage of the stem cells’ flexibility.”

Sir Richard Sykes, chair of the UK Stem Cell Foundation, said Dr Muraro’s research was the first of its kind to take place in the UK.

“Given the high incidence of MS in the UK in comparison to other countries, I am delighted that we have at last progressed stem cell research to this stage, which will bring much-needed hope to so many people affected by this devastating condition.”

The MS Society is also funding two other stem cell studies.

One, based at Queen Mary Hospital, London will examine how stem cells made from the brains of aborted foetuses can be used to repair nerve damage in people with MS.

The other, based at the University of Nottingham, will compare stem cells from people with a progressive form of MS to those without the condition to aid the discovery of effective treatments.

Source: BBC News © British Broadcasting Corporation 2011 (29/07/11

Related articles

• Non-Embryonic Stem Cell Research is a Breakthrough! (summit4stemcell.wordpress.com)
• A Victory for Stem Cell Research and Patients (whitehouse.gov)
• Stem cell trials for MS treatment (independent.co.uk)
• Stem cell trial to treat MS (bbc.co.uk)
• Stem cell treatment ‘could prevent MS brain damage’ (telegraph.co.uk)
• New push in Austin for adult stem cell therapy (earlsview.com)
• Trials for stem cell MS treatment (mirror.co.uk)

Doctors begin major stem cell trial for MS patients

A major clinical trial will investigate whether stem cells can be safely used to treat multiple sclerosis (MS).

It is hoped eventually to slow, stop or even reverse the damage MS causes to the brain and spinal cord.

The trial, involving up to 150 patients across Europe, is due to start later this year.

Dr Paolo Muraro from Imperial College London said: “There is very strong pre-clinical evidence that stem cells might be an effective treatment.”

Researchers will collect stem cells from the bone marrow of patients, grow them in the laboratory and then re-inject them into their blood.

The stem cells will make their way to the brain where it is hoped that they will repair the damage caused by MS.

The research has been part-funded by the UK’s MS Society, which is concerned about the availability of unproven stem cell treatments.

In recent years many people living with MS have been attracted to overseas stem cell clinics which claim to cure long-term conditions in exchange for large amounts of money.

But there is no proven stem cell therapy available for MS anywhere in the world.

The MS Society hopes these new trials will eventually lead to a proven treatment – and a reduction in the draw of overseas treatments.

Common condition

MS is the most common neurological condition to affect young people in the UK.

Three million people are thought to be affected worldwide and up to 100,000 in the UK.

The condition is caused by the body’s own immune system attacking and damaging a substance called myelin in the brain and nerve cells.

The myelin damage disrupts messages from the brain to the body which leads to a number of symptoms such as sight loss, bladder and bowel problems, muscle stiffness and eventually physical disability.

Drugs are available to alleviate the symptoms – but they do not prevent the progression of the condition.

Experiments in test tubes and laboratory animals suggest stem cells extracted from bone marrow may be able to offer a more effective treatment.

Their role in the bone marrow is to protect the cells that make blood. But they also seem to protect myelin from attack by the immune system.

There is also some evidence that these cells might also be able to repair damaged tissue.

Hold potential

Dr Doug Brown, of the MS Society, said: “These experiments have confirmed that these stem cells hold that potential – but these need to be confirmed in large scale clinical trials.”

There is some way to go, however, before laboratory promise can be translated into a treatment that can be offered to patients.

The international team will begin so-called phase two clinical trials in six months’ time designed to determine whether the treatment is safe and effective.

It will take five years to carry out and assess the results of the trials after which large phase three trials may be required.

But Dr Muraro believes that the stem cell approach has real potential.

He said: “The great hope is the fact that we are exploiting a biological system that has evolved over millions of years and harnessing it for treatment that takes advantage of the stem cells’ flexibility.”

Sir Richard Sykes, chair of the UK Stem Cell Foundation, said Dr Muraro’s research was the first of its kind to take place in the UK.

“Given the high incidence of MS in the UK in comparison to other countries, I am delighted that we have at last progressed stem cell research to this stage, which will bring much-needed hope to so many people affected by this devastating condition.”

The MS Society is also funding two other stem cell studies.

One, based at Queen Mary Hospital, London will examine how stem cells made from the brains of aborted foetuses can be used to repair nerve damage in people with MS.

The other, based at the University of Nottingham, will compare stem cells from people with a progressive form of MS to those without the condition to aid the discovery of effective treatments.

Source: BBC News © British Broadcasting Corporation 2011 (29/07/11

Related articles

• Non-Embryonic Stem Cell Research is a Breakthrough! (summit4stemcell.wordpress.com)
• A Victory for Stem Cell Research and Patients (whitehouse.gov)
• Stem cell trials for MS treatment (independent.co.uk)
• Stem cell trial to treat MS (bbc.co.uk)
• Stem cell treatment ‘could prevent MS brain damage’ (telegraph.co.uk)
• New push in Austin for adult stem cell therapy (earlsview.com)
• Trials for stem cell MS treatment (mirror.co.uk)